- Rothmann, M. D., Wiens, B. L. and Chan, I. S. F. (2011). Design and Analysis of Non-Inferiority Trials. Chapman & Hall/CRC, Boca Raton, USA.
- Ng, Tie-Hua. (2014). Noninferiority Testing in Clinical Trials: Issues and Challenges. Chapman & Hall/CRC.
How should I design a biostatistic model for the treatment of the lung cancer if this novel treatment will benefit the victims with the stage IV by changing their natural courses to the stage I?
A： I am not familiar with the treatment changing the natural course of stage IV lung cancer to the stage I, so I am sorry for not being able to offer you any suggestion.